- Lightning McQueen: "Whoa, look at that. Look, they're drivin' right by. They don't even know what they're missing!"
Sally: "Well, it didn't used to be that way."
Lightning McQueen: "Oh, yeah?"
Sally: "Yeah. Forty years ago, that Interstate down there didn't exist."
Lightning McQueen: "Really?"
Sally: "Yeah. Back then, cars came across the country a whole different way."
Lightning McQueen: "How do you mean?"
Sally: "Well, the road didn't cut through land like that Interstate. It moved with the land, you know? It rose, it fell, it curved."
- —Lightning McQueen and Sally, talking about I-40
Interstate 40 is a United States interstate running from Barstow, California, to North Carolina. In the 2006 Pixar film Cars, Interstate 40 is very popular. Lightning McQueen and Mack start their drive to Los Angeles from the Motor Speedway of the South in Nashville, Tennessee, and during the "Life is a Highway" sequence, they are seen driving west on Interstate 40. The interstate is also responsible for by passing Radiator Springs to save 10 minutes of driving, according to Sally, causing Radiator Springs to lose all its visitors and customers. But when McQueen became famous and sets up his racing headquarters there, people returned to Radiator Springs. The Top Down Truckstop is located along Interstate 40.
Mack was driving down Interstate 40, when the Delinquent Road Hazards come and plan to rob him. DJ puts him to sleep with music, Boost jumps on top of his trailer using a ramp pulled by Snot Rod, which causes the door to open; and Wingo grabs all of Lightning's gear that falls out. Then they run away before Snot Rod sneezes and wakes up Mack. Mack realizes what happens. He pulls over and calls Sheriff to tell what happened.